Fig. 3

Effect of micro-topographical cues in vivo. a Schematic of the effect of radial topography on regeneration of critical-sized bone defect. b Representative micro-CT image. c Quantitative analysis of micro-CT imaging of bone regeneration after 4 wk. and 6 wk. of regenerative repair (n = 5 per sample). d Micrograph of hematoxylin and eosin (H&E) staining and quantitative analysis of bone density using the H&E images