Fig. 1

Eye structure and AMD pathology. A Physiology structure of an entire eye. B Enlarged description of macular and Bruch’s membrane structure. C Pathology of dry AMD, including drusen deposition (yellow) and RPE elevation. D Pathology of 3 types of wet AMD. Type 1 macular neovascularization (MNV) is an ingrowth of vessels without outer retinal disruption. Type 2 MNV is the proliferation of new vessels with outer retinal disruption. Type 3 MNV is a downgrowth of vessels from the retinal vascular plexus toward the outer retina [22]