Fig. 6

Exosomes from heat shock preconditioned BMSCs ameliorated cisplatin-induced cochlear NLRP3 inflammasome activation. NLRP3, ASC, cleaved caspase-1, and pro-caspase-1 expression in the cochlear tissues were detected with Western blotting (A). The expressions were normalized to internal control (B-E). The data were shown with mean ± SD. The experiments were repeated 3 times with homogenate from 6 mice in each group. **p < 0.01, ***p < 0.001 compared to control, #p < 0.05, ##p < 0.01 compared to Cisplatin, ^p < 0.05, ^^p < 0.01 compared to Cisplatin + Exo. One-way ANOVA followed Tukey’s multiple comparisons test