Fig. 6

Transcriptomics analysis for the spheroid culture (SC) group. A Principal component analysis exhibited obvious differences between the two groups. B The volcano plot showed 1041 DEGs were up-regulated and 568 DEGs were down-regulated in the SC group. C The 15 significantly enriched signaling pathways based on DEGs. D The 15 significantly enriched Gene Ontology (GO) biological process (BP) terms based on DEGs