Fig. 7

Heatmaps and gene validation of major GO-BP terms and KEGG pathways. A The heatmaps of cell adhesion and ECM organization in GO-BP analysis. B, C The heatmaps of tight junction, cell adhesion molecules and ECM-receptor interaction in KEGG enrichment analysis. D, E RT-qPCR results of mRNA expression for CDH1, CDH2, CYP1B1, ITGA3, COL1A2, SPARC, RDX, EZR in the NC and SC group. Mean ± SD (*p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001; n = 3)