Table 1 Summarizes some classical examples about the application of MSC-Exos in different tissue repairs
From: Role of mesenchymal stem cell-derived exosomes in the regeneration of different tissues
MSCs source of Exos | Application/purpose | Method of Exos isolation | Effectiveness/results | References |
|---|---|---|---|---|
Bone marrow mesenchymal stem cells | MSC-Exos can enhance neurogenesis and restore cognitive function lost by administration of Aβ1–42 aggregates | Ultracentrifugation | As a possible therapeutic strategy for the treatment of chronic degenerative neurologic diseases. | 27 |
Human adipose mesenchymal stem cells | MSC-Exos were found to contribute to the recovery of PD by promoting ICAM1-related angiogenesis. | Ultracentrifugation | MSC-Exos can promote the angiogenesis of human brain microvascular endothelial cells, with possible therapeutic potential for Parkinson’s disease. | 37 |
Rat bone marrow mesenchymal stem cells | Exosomes secreted from CXCR4 overexpressing mesenchymal stem cells promote cardioprotection via Akt signaling pathway following myocardial Infarction | Polymer coprecipitation method | Cardiac functions were improved by transplantation of exosome-treated MSC via increased angiogenesis in the infarcted heart. | 42 |
Human umbilical cord mesenchymal stem cells | HucMSC-Exos can regulate necroptosis through miR-874-3p to attenuate renal tubular epithelial cell injury and enhance repair | Filtration + ultracentrifugation | This study provides new therapeutic modalities and ideas for the treatment of AKI and the process of AKI to CKD transformation to mitigate renal damage. | 55 |
Adipose-derived mesenchymal stem cells(ADMSC) | Adipose-derived mesenchymal stem cell exosomes suppress hepatocellular carcinoma growth in a rat model | Filtration + ultracentrifugation | ADMSC-derived exosomes promoted NKT-cell antitumor responses in rats, thereby facilitating HCC suppression | 58 |
Human mesenchymal stem cells | MSCs derived exosomal lncRNA KLF3-AS1 transplantation could facilitate cartilage repair by promoting chondrocyte proliferation and inhibiting apoptosis via miR-206/GIT1 axis | Polymer coprecipitation method + ultracentrifugation | Exosomes derived from mesenchymal stem cells have potential therapeutic effects on osteoarthritis | 67 |
Human gingival tissue-derived MSCs | Exosomes from TNF-α-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss | Filtration + ultracentrifugation | TNF-α-preconditioned GMSC-derived exosomes may be a promising therapeutic tool against periodontitis | 72 |