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Fig. 2 | Journal of Biological Engineering

Fig. 2

From: Oxygenator assisted dynamic microphysiological culture elucidates the impact of hypoxia on valvular interstitial cell calcification

Fig. 2

Relative mRNA expression of genes regulated by hypoxia in hVICs cultured for 24 h in dynamic MPS culture with different oxygen concentrations in comparison to static control and related to dynamic MPS culture at 19% oxygen. Hypoxia inducible factors HIF1α and HIF2α and its regulators EGLN1,2,3 (prolyl hydroxylases) and the HIF effector LDHA were quantified. (one-way ANOVA and Tukey-test or Friedmann and Dunn`s-test, respectively; *p < 0.05; **p < 0.01; ***p < 0.005; ****p < 0.0001)

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Journal of Biological Engineering

ISSN: 1754-1611