Fig. 1
From: Engineering Yarrowia lipolytica for the production of β-carotene by carbon and redox rebalancing
Construction of the base strain for β-carotene production. A Scheme illustrating the engineered metabolic nodes of β-carotene production, including synthetic and mevalonate pathways. Dashed arrows represent multiple metabolic reactions in between. CarRP, phytoene synthase/lycopene cyclase; CarB, phytoene dehydrogenase; ERG20, farnesyl pyrophosphate synthetase; GGPPS, geranyl geranyl diphosphate synthase; HMGR, hydroxymethylglutaryl-CoA reductase; ERG12, mevalonate kinase. B Carotenoid production and specific growth rate of derivative strains. Each plus sign represents a single round of integration of corresponding gene expression cassettes into the genome. Error bars represent the standard deviations of three biological replicates