Table 1 Comparison of different technologies for off-gas analysis in shake flasks
From: A new approach to off-gas analysis for shaken bioreactors showing high CTR and RQ accuracy
Measurement System | Aeration | Data Output | Measurement principle | Sensor technology | Sensor placement |
|---|---|---|---|---|---|
RAMOS [55] | Active | OTR/CTR | Partial pressure change in measurement phase | Electrochemical/Pressure | Flask |
CDMSS [15] | Passive | O2/CO2 in the gas phase | Partial pressure | Fluorescence/NDIR | Bypass |
Triple disposable non-invasive sensors [16] | Passive or active | O2/CO2 in the gas phase | Partial pressure | Fluorescence | Flask or Off-gas stream |
BCpreFerm [54] | Passive | O2/CO2 in the gas phase | Partial pressure | Zirconium dioxide/NDIR | Flask |
TOM | Active | OTR/CTR | Partial pressure change in measurement phase | Electrochemical/NDIR | Bypass |