An electrochemical biosensor for the detection of microRNA-31 as a potential oral cancer biomarker

Table 1 A comparative analysis of the fabricated MiRNA biosensor in relation to other documented electrochemical biosensors for MiRNA detection

Electrode	Recognition element	Target	Signaling element	Electrochemical technique	LOD	References
Pencil graphite	MWCNTs	miRNA-125	[Fe(CN)₆]^3−/4−	EIS	10 pM	[61]
Glassy carbon	MoS₂/Thi/AuNPs	miRNA-21	Thionine	SWV	0.26 pM	[62]
Glassy carbon	Graphene/PBSE	miRNA-21	[Fe(CN)₆]^3−/4−	EIS	3 fM	[41]
FTO	SWCNTs den-Au	miRNA-21	[Fe(CN)₆]^3−/4−	DPV	0.01 fM	[63]
HRCA-strip platform	(StrepMBs) with biotin-modified DNA probes	miRNA-31	[Fe(CN)₆]^3−/4−	-	3.21 fM	[64]
Gold	MCH	miRNA-21	[Fe(CN)₆]^3−/4−	DPV/EIS	0.6 pM	[65]
Paper	AuNPs/rGO	miRNA-21	[Fe(CN)₆]^3−/4−	DPV	12 nM	[66]
Paper	AuNPs/rGO	miRNA-155	[Fe(CN)₆]^3−/4−	DPV	25.7 nM	[66]
Glassy carbon	Graphene	miRNA-31	[Fe(CN)₆]^3−/4−	EIS	10 pM (buffer) 100 pM (serum)	This work

MWCNTs, multi walled carbon nanotubes; EIS, electrochemical impedance spectroscopy; MoS₂, Molybdenum disulfide; Thi, thionine; AuNPs, gold nanoparticles; SWV, square-wave voltammetry; PBSE, 1-pyrenebutyric acid-N-hydroxysuccinimide ester; FTO, fluorine-doped tin oxide; SWCNTs, single walled carbon nanotubes, den-Au, dendritic gold; DPV, differential pulse voltammetry; HRCA, hyper-branched rolling circle amplification; StrepMBs, Group B Streptococcus magnetic beads; MCH, Melanin-concentrating hormone; rGO, reduced graphene oxide

ISSN: 1754-1611