An electrochemical biosensor for the detection of microRNA-31 as a potential oral cancer biomarker

Table 2 A comparison table of various targets with different sensing methods for the detection of oral cancer biomarkers

Biomarker	Method	Analyte	Detection limit	References
IL-8	CV/EIS	Human serum and saliva	3.3 fg/mL	[67]
IL-6	Amperometry	Human serum	0.5 pg/mL	[68]
MMP-7	Amperometry	Human serum	1 ng/mL	[69]
ORAOV1	CV/DPV	Artificial saliva	3 fg/mL	[70]
miRNA-200a	Chronoamperometry	Artificial saliva	2.2 × 10⁻¹⁹ M	[71]
HIF-1α,	Amperometry	Human saliva	76 pg/mL	[72]
miRNA-31	EIS	Buffer Human serum	70 pg/mL 700 pg/mL	This work

Abbreviations IL-8 – Interleukin-8, IL-6 – Interleukin-6, MMP-7 - Matrix Metalloproteinase-7, ORAOV1 - Oral cancer overexpressed 1, HIF-1α - Hypoxia-inducible factor 1-alpha, CV – Cyclic Voltammetry, EIS – Electrochemical Impedance Spectroscopy, DPV – Differential Pulse Voltammetry

ISSN: 1754-1611