Table 2 Heterologous HA productions in various engineered strains

E. coli

Class I (Streptococcus pyogenes)

16 g/L glucose

190 mg/L, f

0.35 MDa

[6]

B. subtilis

Class I (Str. equisimilis)

20 g/L sucrose

2.26 g/L, b

0.35 ∼ 1.9 MDa

[10]

C. glutamicum

Class I (Str. equisimilis)

625 g/L glucose

28.7 g/L, b

0.21 ∼ 0.9 MDa

[8]

C. glutamicum

Class I (Str. pyogens)

400 g/L glucose

74.1 g/L, b

0.053 MDa

[9]

E. coli

Class II (Pasteurella multocida)

50 g/L glucose

3.8 g/L, b

1.5 MDa

[7]

Komagataella pastoris

Class I (Xenopus laevis)

20 g/L glucose

0.17 g/L, b

2.5 MDa

[11]

Synechococcus sp. PCC 7002

Class I (Str. equisimilis)

1% (v/v) CO₂ and air

112 mg/L, a

2 ∼ 2.2 MDa

[17]

Syn. elgonatus. PCC 7942

Class I (Str. zooepidemicus)

5% (v/v) CO₂ and air

5 mg/L, a

4.2 MDa

This study