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Table 2 Association and dissociation rate constants (ka and kd), and equilibrium dissociation constants (KD) in the interaction of trastuzumab and trastuzumab-Fc variants with hFcRn at pH 6.0

From: Engineering FcRn binding kinetics dramatically extends antibody serum half-life and enhances therapeutic potential

 

ka (M− 1s− 1)

kd (s− 1)

KD (nM)

Trastuzumab

Steady state

4360

Trastuzumab-DHS

3.57 × 104

0.0645

1800

Trastuzumab-PFc29

3.98 × 104

0.0721

1810

Trastuzumab-YML

6.32 × 104

0.0555

878

Trastuzumab-EML

2.85 × 104

0.0475

1670

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Journal of Biological Engineering

ISSN: 1754-1611