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Table 3 Thermostabilities (Tm) of trastuzumab and trastuzumab-Fc variants

From: Engineering FcRn binding kinetics dramatically extends antibody serum half-life and enhances therapeutic potential

Name of Fc variants

Apparent Tm (°C)

pI

Mw (kDa)

Trastuzumab

69.03±0.14

8.76

148.84

Trastuzumab-DHS

68.74±0.49

8.55

148.82

Trastuzumab-PFc29

69.00±0.10

8.67*

148.87

Trastuzumab-YML

67.57±0.05

8.75

148.92

Trastuzumab-EML

67.30±0.22

8.58

148.85

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Journal of Biological Engineering

ISSN: 1754-1611