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Fig. 1 | Journal of Biological Engineering

Fig. 1

From: Design of a prodrug bispecific antibody masked by a functional molecule for lymphocyte activation for cancer therapy

Fig. 1

Schematic illustrations of (a) the gene construction of scFv-MMP-Ex3 as a representative and (b) the amino acid sequences of the linker containing the matrix metalloprotease (MMP) recognition sequence. 9H and 9L represent the VH and VL regions of anti-4-1BB scFv (clone: 94G1). h5H and h5L show the VH and VL regions of the humanized anti-epidermal growth factor receptor (EGFR) antibody 528, and hOH and hOL represent the VH and VL regions of the humanized anti-CD3 antibody OKT3. (c) A schematic representation of the working mechanism of scFv-MMP-Ex3 prodrug to exert the tumor-specific activation upon the cleavage by MMP highly expressed in cancer cells

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Journal of Biological Engineering

ISSN: 1754-1611